Anatoly Anatolievich Manykin
Lead Researcher, Chief of the Laboratory of Virus Structure and Morphogenesis, Doctor of Biological Sciences, Professor.
In 1965, he graduated the Physics Faculty of the M.V. Lomonosov Moscow State University,trained as physical scientist (diploma F No. 126088), the Chair of Biophysics. Degree thesis on the topic of: “Study of a Complex of Nucleic Acids with Pinacyanol”. From 1965 to 1968, he worked as an Engineer at the N.F. Gamaleya Center of Epidemiology and Microbiology, at the Laboratory of Anatomy of Microorganisms. In 1968–1971, he underwent the postgraduate training at the D.I. Ivanovsky Research Institute of Virology, at the Laboratory of Virus Structure and Morphogenesis (Laboratory Chief and Head of the Postgraduate Training Program, Professor S.M. Klimenko). In 1972, after defense of a dissertation on the topic: “Experimental Determination of the Time of T2 Bacterial Virus DNA Injection and Analysis of Possible Physical Mechanisms of This Process”, he was awarded the degree of the Candidate of Biological Sciences (diploma MBL No. 015931 dated 30.06.1972). From 1972 to 1980, he was a Junior Research Fellow, then (from 1980) Senior Researcher, and later (from 1994) Lead Researcher of the laboratory. In 1985, he was awarded the academic title of Senior Researcher in the field of Virology (certificate SN No. 040410 dated 08.05.1985). During his work, he trained 5 students for degree thesis defense (M.V. Lomonosov Moscow State University – 3, Moscow Engineering Physics Institute — 1, Veterinary Academy — 1). In 1994, after defense of a dissertation on the topic: “Study of the Structure of Viral Nucleic Acid and Nucleoproteids, Using the Method of Electronic Microscopy”, he was awarded the degree of the Doctor of Biological Sciences in the field of Molecular Biology (Doctor of Sciences Diploma Dr No. 001333 dated 06.05.1994).
During the period of his work, 5 postgraduate students were prepared for thesis defense and became candidates: N.B. Matsko (Cand. Sc. Physics and Mathematics, 2001), F.V. Lisitsin (Cand. Sc. Biology, 2002), A.A. Ryazantseva (Cand. Sc. Biology, 2005), V.A. Yakovleva (Cand. Sc. Biology, 2009) and Naumenko (Cand. Sc. Medicine, 2009) and, in 2010, he was awarded the academic title of Professor in the field of Molecular Biology (certificate series APS No. 001277).
Main fields of scientific activities:
1) Structural organization of bacteriophages, phage DNA inside the head, phage nucleic acid ejection mechanism, as well as morphology of various phage particles in non-culturable equine virus community.
2) Structure and organization of virions of some animal and human viruses (alphavirus, adenovirus, influenza virus and parainfluenza), as well as heteroduplex analysis of viral nucleic acids and complexes of viral DNA with intravirionic proteins.
3) Morphological and molecular-biological indication of human papilloma virus in the infected tissue in case of cervix papillomatosis and cancer. development of a papillomatosis treatment method using contact thermolaser therapy.
During the period of work for the Research Institute of Virology, 87research papers on this topics have been published, not to mention speaking notes, 4 inventor’s certificates and 1 patent on a treatment method have been obtained. A medical device for papillomatosis treatment has been developed.
For the past 10 years, A.A.Manykin has delivered a course of lectures on human papilloma virus infections and electronic microscopy methods at the Chair of Virology, Department of Post-Degree Training, I.M.Sechenov Medical University. He is also an author of the Virus Atlas and co-author of two manuals on virology under the editorship of D.K.Lvov.
In the end of 2016, after Academician S.M. Klimenko passed away, Professor A.A. Manykin headed the Laboratory of Virus Structure and Morphogenesis.