Marina Ridovna Bobkova
Education: 1974–1980 – N.I. Pirogov 2nd Moscow Medical institute, specialty: biochemistry; 1980–1992 – D.I. Ivanovsky Institute of Virology of the Academy of Medical Sciences of the USSR, post-graduate studies in molecular biology, defense of her thesis for the candidate of biological sciences degree; 2002 – Central Research Institute of Epidemiology of Rospotrebnadzor of the Russian Federation, defense of the thesis for the doctor of biological sciences degree on the topic of Molecular and Genetic Methods in Studying Epidemiology of Infections Whose Agents are Transferred Parenterally.
Professional field:
organization of molecular and genetic monitoring of the HIV infection in Russia and the CIS;
organization of works for monitoring of HIV drug resistance in Russia and the CIS;
development of training programs on HIV biology and diagnostics for regional AIDS centers for AIDS prevention and fighting; development of approaches to prognosis of the course of the HIV infection and the response to treatment, based on the human genome analysis. The length of work in healthcare is 34 years.
Work experience:
1980–1985 – D.I. Ivanovsky Institute of Virology of the Academy of Medical Sciences of the USSR, post-graduate student. Key activities: studying bacterial toxin genes, development of immunotoxins with specific cytotoxicity
1985–1996 – D.I. Ivanovsky Institute of Virology of the Academy pf Medical Sciences of the USSR, researcher.
Key activities: participation in fundamental and application studies of the biology and molecular epidemiology of HIV-1, hepatitis C virus, and type 1 T-lymphotropic virus
1992–1996 – I.I. Mechnikov Research Institute of Vaccines and Serums, senior researcher
Key activities: development of immunoenzymometric test systems for virus infection diagnostic
1996–2005 – Russian Research Guidance Center for AIDS Prophylaxis and Fighting, lead researcher.
Key areas: studies as a part of research projects, development of research guidance recommendations on HIV and virus hepatitis diagnostics, participation in training seminars
2005 – now – D.I. Ivanovsky Institute of Virology of the Ministry of Healthcare of the Russian Federation / D.I. Ivanovsky Institute of Virology of the Ministry of Healthcare of the Russian Federation of N.F. Gamaleya Research Center of Epidemiology and Microbiology of the Ministry of Healthcare of the Russian Federation, head of the general virology department.
Key activities: organizing and conducting studies, drawing up scientific projects, training young professionals, conducting seminars for healthcare professionals
Examination activities: accredited as an expert in the Russian Fundamental Research Fund and the Federal Register of Research and Development Experts.
Languages: fluent English
Scientific awards, societies
Russia's representative in the European Society for translational Antiviral Research, 201 Russia's representative in the European HIV Drug Resistance Guidelines Panel, 2014
Member of the International AIDS Society
Member of the All-Russia Society of Infection Disease Doctors
Award of the Russian Academy of Medical Sciences for the Best Research Work in Molecular Virology, 2009
Award of the State Library Named After V.I. Lenin for the Immunity and HIV Infection monograph, 2007
Member of the editorial staff of the HIV Infection and Immunosuppression Disorders journal
200 publications, 4 monographs.
Articles of 2010–2014
1. Kolomeets AN, Varghese V, Lemey P, Bobkova MR, Shafer RW. A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses. AIDS. 2014 Nov 13;28(17):F1-8.
2. Kazennova E, Laga V, Lapovok I, Glushchenko N, Neshumaev D, Vasilyev A, Bobkova M. HIV-1 genetic variants in the Russian Far East. AIDS Res Hum Retroviruses. 2014 Aug;30(8):742-52.
3. Lapovok I, Kazennova E, Laga V, Vasilyev A, Utegenova A, Abishev A, Dzissyuk N, Tukeev M, Bobkova M. Molecular epidemiology of HIV type 1 infection in Kazakhstan: CRF02_AG prevalence is increasing in the southeastern provinces. AIDS Res Hum Retroviruses. 2014 Aug;30(8):769-74.
4. Bobkova M.R. HIV drug resistance. Chelovek, Moscow, 284 p. (monograph).
5. Kazennova E.V., Neshumaev D.A., Rukavitsin D.V., Lapovok I.A., Laga V.Y., Rakcheeva O.V., Vasilyev A.V., Tumanov A.S., Vorontsova G.A. Kuznetsova A.V., Loyfman E.A., Starukhina I.N., Kustova O.I., Polovitsa N.V., Lipskaya N.A., Bobkova M.R. Molecular and epidemiological analysis of the HIV epidemic in Blagoveshchensk and Khabarovsk (Far East of Russia). Problems of Virology, 2014, 59 (4): 31-36.
6. Bobkova M. Current status of HIV-1 diversity and drug resistance monitoring in the former USSR. AIDS reviews, 2013, vol.15, N 4, pp. 204-212.
7. Gkikas Magiorkinis, Dimitrios Paraskevis, Oliver-George Pybus, Timokratis Karamitros, Tetyana Vasylyeva, Marina Bobkova, Angelos Hatzakis. HIV-1 epidemic in Russia: an evolutionary epidemiology analysis. The Lancet, Volume 383, Page S71.
8. Virology guideline: human and animal viruses and viral infections. Under the editorship of Lvov D.K. (two chapters in the book). – M: MIA. 2013. – 1,300 p. (M.R. Bobkova – Retroviruses. HIV infection and AIDS).
9. Kazennova E.V., Vasilyev A.V., Lapovok I.A., Grishechkin A.E., Laga V.Y., Salamov G.G., Tumanov A.S., Parygina O.A., Ruzarva L.A., Grezina L.A., Serkina P., Kaufman O.A., Iirzhak D., Lukashov V.V, Bobkova M.R. Genetic variants of HIV-1 in the Asian part of Russia (2005–2010). Problems of Virology, 2013, 58 (4): 28-35.
10. Nikitina E.G., Dmitrieva L.V., Bronnikova S.N., Zarubin S.N., Pashkovskaya M.Y., Plotnikova Y.K., Bobkova M.R. Optimization of the HIV infection laboratory diagnostics at the confirmation stage of testing. HIV Infection and Immunosuppression Disorders, 2013, 5 (2): 97-104
11. Kazennova E.V., Lapovok I.A., Laga V.Y., Vasilyev A.V., Bobkova M.R. Natural polymorphisms of the pol gene of the IDU-A HIV-1 variant. HIV Infection and Immunosuppression Disorders, 2012, N 4, p. 44-51.
12. I Lapovok, V Laga, A Vasilyev, E Kazennova, E Ludvikova, N Kovtunenko, N Dzisyuk, M Tukeev, M Bobkova. Analysis of HIV-1 primary drug resistance in Kazakhstan. Journal of the International AIDS Society 2012, 15(Suppl 4):182097.
13. Laga V.Y., Kazennova E.V., Vasilyev A.V., Lapovok I.A., Ismailova A., Beysheeva N., Asybalieva N., Bobkova M.R. Molecular and genetic characteristic of HIV-1 variants spread in Kyrgyzstan. Problems of Virology, 2012, 57 (5): 26-32.
14. Vasilyev A.V., Akhmerov K.R., Salamov G.G., Kazennova E.V., Bobkova M.R. Analysis of polymorphism of HIV-1 genome region coding the fusion protein. Problems of Virology, 2012, 57 (4): 9-13.
15. Bobkova M.R. Drug resistance to nevirapine in mothers and newborns. Problems of Virology, 2011, 56 (5): 47-49.
16. Kazennova E.V., Antonova O.V., Kuzin S.N., Serkina E.P., Sokolova S.S., Vasilyev A.V., Lapovok I.A., Bobkova M.R. Molecular and genetic study of HIV-1 variants spread in the Republic of Sakha (Yakutia) // Problems of Virology, 2011, Volume 56, No. 5, p. 30-34.
17. Vasilyev A.V., Kazennova E.V., Bobkova M.R. Analysis of prevalence of mutations of drug resistance to CCR5 coreceptor antagonists in HIV-1 variants in Russia // Problems of Virology, 2011, Volume 56, No. 3, p. 33-37.
18. Tumanov A.S., Laga V.Y., Kazennova E.V., Kozyrev O.A., Sotnikov V.P., Kulagin V.V., Tonkikh O.S., Khafizov K.M., Ulyanina N.I., Rakhmanova A.G., Petemina L.P., Tsybakova O.A., Vdovina V.N., Olshansky A.Y., Bobkova M.R. HLA-B*5701 allel prevalence in the European part of the Russian Federation. // Medical Genetics. - 2010. - V. 9.- No. 8. - p. 36-39.
19. Kazennova E.V., Lapovok I.A., Vsilyev , Laga V.Y., Grezina L.A., Volova L.Y., Bobkova M.R. Problems of HIV-1 subtyping based on analysis of the pol gene and ways of their solving // HIV Infection and Immunosuppression Disorders, 2010, Volume 2, No. 3, p. 42–48
20. Tumanov A.S., Kazennova E.V., Bobkova M.R. Development and optimization of methods of determining MDR1 human gene alleles and assessment of their prevalence in Russia // Molecular Medicine, 2010, No,2, p. 39–43
Experience in research project management
1. European Union Project FP7, Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN), N 223131, 2009-2014. http://ec.europa.eu/research/health/infectious-diseases/poverty-diseases/projects/185_en.htm.
2. Governmental Contract No. K-24-FTsP/305-1 – Molecular and Epidemiological Monitoring of HIV Infection in Russia, Ministry of Healthcare of the Russian Federation, 2009.
3. Governmental Contract No.K-24-FTsP/125-4 – Molecular and Epidemiological Analysis of the Main Genetic Variants of HIV-1 and Their Prevalence in Various Contamination Risk Groups in Russia, Ministry of Healthcare of the Russian Federation, 2011. 4. Governmental Contract No. K-24-FTsP/125-5 Predicting Efficiency of New Antiretroviral Drugs Based on Assessment of Genetic Specifics of HIV-1 Variants Circulating in Russia, Ministry of Healthcare of the Russian Federation, 2011. 5. Governmental Contract No. 8148, Ministry of Education and Science of the Russian Federation, Molecular Epidemiological Characteristics of the HIV Epidemic in Siberia and the Far East of Russia, 2012–2013.
6. Governmental Contract No. 8154, Ministry of Education and Science of the Russian Federation, Assessment of Genetic Integrase Polymorphism of HIV-1 Strains Prevailing in Russia, 2012–2013.
7. Governmental Contract No. 8479, Ministry of Education and Science of the Russian Federation, Prediction of the Course and the Efficiency of HIV Infection Therapy Based on Analysis of Human Genome Markers, 2012–2013.
8. Project of the International Science and Technology Center N 3826 Genetic Polymorphism of HIV-1 in the Former USSR Republics, 2008–2011.
9. Project of the International Science and Technology Center N U-1582 Role of the Secondary DNA Structure in the HIV-1 Replication Process: Study Using the Methods of Molecular Genetics , Phylogenetics, and Bioinformatics, 2008–2010.